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Over the counter Antifungal medications and creams are used to treat fungal infections that affect your skin, hair and nails. Antifungals work by either killing the fungal cells, or by preventing the fungal cells growing and reproducing. A common Antifungal medication is Miconazole which can help with skin infections such as athlete's foot, jock itch, ringworm, and other fungal skin infections. Miconazole works by preventing the growth of fungus.